Protein hot spots at bio-nano interfaces
Volume 14, Issues 7–8, Page 360–365
| Gerald F. Audette, Stephanie Lombardo, Jonathan Dudzik, Thomas M. Arruda, Michal Kolinski, Slawomir Filipek, Sanjeev Mukerjee, Arunachala Mada Kannan, Velmurugan Thavasi, Seeram Ramakrishna, Michael Chin, Ponisseril Somasundaran, Sowmya Viswanathan, Resat S. Keles, Venkatesan Renugopalakrishnan
Nanotechnology has influenced the direction of research across the sciences, medicine, and engineering. Carbon nanotubes (CNTs) and, more recently, protein nanotubes (PNTs) and protein-inorganic nanocomposites have received considerable attention due to their unique nanostructures that can be utilized as a scaffold to house proteins or create nanowires. A shift towards protein-inorganic interactions has numerous applications from biosensors to biofuel cells and bio-based nanodevices. We examine several systems where protein hot spots, the active domains on proteins and the interactive dynamics in them, play a critical role in the interactions at the interface of these unique systems.
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DOI: 10.1016/S1369-7021(11)70167-5
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