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Antibody sensed protein surface conformation - Current research article


Scott R. Schricker, Manuel L.B. Palacio, and Bharat Bhushan

An antibody-modified atomic force microscope tip was used to detect conformational changes of fibronectin deposited on a poly(methyl methacrylate)/poly(acrylic acid) block copolymer compared to PMMA and a random poly(methyl methacrylate)/poly(acrylic acid) copolymer with an identical chemical composition.

Upon implantation into a living host, biomaterial surfaces are rapidly coated with a dynamic protein layer. The interactions of this protein layer and cells with biomaterial surfaces are widely studied because of their implications to a wide range of applications, such as the development of new materials for cell culture, dental and surgical implants and biosensors.

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Materials Today (2011) 14(12), 616-621
doi: 10.1016/S1369-7021(11)70303-0

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This article is featured in:
Biomaterials  •  Tools and Techniques