Cell migration induced by gradients of cell-secreted soluble molecules across collagen posts.

Casting a new light on chromophores
Researchers from Harvard University in Massachusetts have devised a method to study non-fluorescent molecules using a technique called stimulated emission microscopy, an approach based upon a phenomenon first described by Albert Einstein in 1917 [Min et al., Nature (2009) 461, 1105].
Engineered bone dependant on cell source
Scientists [Gentleman et al., DOI: 10.1038/NMAT2505 ] have successfully highlighted the importance of cell source in regenerative medicine.
Nanoscale ‘stealth’ probe
Engineers at Stanford have created a nanoscale probe they can implant in a cell wall without damaging the wall. [Almquist and Melosh, PNAS (2010) 107, 5815.]
Nanoscale 'stealth' probe
Engineers at Stanford have created a nanoscale probe they can implant in a cell wall without damaging the wall.
Biomimetic materials in tissue engineering
Biomaterial matrices are being developed that mimic the key characteristics of the extracellular matrix, including presenting adhesion sites and displaying growth factors in the context of a viscoelastic hydrogel. This review focuses on two classes of materials: those that are derived from naturally occurring molecules and those that recapitulate key motifs of biomolecules within biologically active synthetic materials.

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Replication of the 3D architecture of tissues

15 February 2010
Raquel Perez-Castillejos

Biological tissues are ensembles of various types of cells and extracellular molecules. Functionality in tissues arises from their components (cells and extracellular molecules) as well as from the location of those components relative to each other. The organization of the constituents of a tissue is known as histoarchitecture.

As cell culture reaches beyond flat, rigid surfaces, several approaches have been published that attempt to re-create in vitro the three-dimensional (3D) histoarchitecture found in vivo.

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