We would like to invite you to submit your work on multifunctional, yet clinically relevant, biomaterials for tissue repair and regeneration to Biomaterials and Biosystems. The prevalence of tissue injuries and pathophysiologies rises and financially drains healthcare systems worldwide in direct proportion to the continuously increasing life expectancy and aging of the human population. Although various natural, synthetic and combinations thereof biomaterials have demonstrated clinical safety, their scattered therapeutic efficacy and efficiency illustrate wanted ability to accurately recapitulate structural, compositional and functional characteristics of targeted injured or diseased tissues. Biomaterials scientists and technologists are therefore urgently required to develop therapeutic interventions to simultaneously minimise and maximise patient distress and quality of life, respectively. In the quest of truly reparative biomaterials, research and development efforts are directed towards (multi) functional, clinical-indication-specific implantable devices that will positively interact with the host and reinstate compromised / lost tissue function and encourage repair and regeneration. Although highly elegant bioinspired biomaterials constitute the state of play in research endeavours, development and translation efforts are lagging behind in sophistication. Despite the fact that contemporary biomaterials have demonstrated powerful reparative capacity, even in phase I clinical trials, this unpresented research success represents a commercial and clinical technology transfer barrier due to complexity, scalability and regulatory constraints. The next generation of implantable devices must therefore be functional enough to induce positive therapeutic outcome and simple enough to stimulate market success. Precise understanding of the mechanism of action of the various device components, scalability and compliance with regulatory frameworks are prerequisites. In this Special Issue, recent developments, existing technological and regulatory challenges and future aspirations in the multifunctional, yet clinically relevant, biomaterials will be discussed.
For more information please follow the link above.
We would like to invite you to submit your work on multifunctional cell- and tissue- derived biomaterials and biosystems for regenerative medicine and drug discovery to Biomaterials and Biosystems. Current approaches for reparative regenerative medicine and precise drug discovery utilise cell-derived matrices and tissue grafts to more accurately capture ex vivo the multifaceted composition of target tissues. After all, one should consider that extracellular matrices are rich sources of bioactive and tropic molecules that, through their properties, regulate cellular activities and processes and contribute in tissue development, morphogenesis and regeneration as well as in disease manifestation, progression and metastasis. In this Special Issue, recent developments, existing technological and regulatory challenges and future aspirations in the field of cell- and tissue- derived biomaterials and biosystems for in vitro cell phenotype maintenance, development of functional and therapeutic implantable devices and prediction of human response to candidate molecules, as indicative examples, will be discussed.
For more information please follow the link above.