Tight-binding models provide a conceptually transparent and computationally efficient method to represent the electronic properties of materials. With AFLOWπ we introduce a framework for high-throughput first principles calculations that automatically generates tight-binding hamiltonians without any additional input. Several additional features are included in AFLOWπ with the intent to simplify the self-consistent calculation of Hubbard U corrections, the calculations of phonon dispersions, elastic properties, complex dielectric constants, and electronic transport coefficients. As examples we show how to compute the optical properties of layered nitrides in the AMN2 family, and the elastic and vibrational properties of binary halides with CsCl and NaCl structure.