Phosphorus-31 capable benchtop NMR spectroscopy system

Phosphorus is commonly found in many organic compounds, for example in biological membranes or DNA. The ³¹P nucleus has a 100% natural isotopic abundance and a large chemical shift range, making it one of the most commonly used nuclei in biological NMR. For the first time users can have the power of proton-phosphorus NMR in a benchtop instrument that can be safely used in the laboratory.

The launch of Spinsolve Phosphorus adds a new member to the successful Spinsolve family of benchtop NMR spectrometers. It has been designed to meet the needs of several groups of users: pharmaceutical and medicinal chemists, synthetic chemists monitoring reactions, industrial chemists measuring purity of their compounds, academics focused on organic chemistry education and researchers or post graduate students doing small molecule structure elucidation.

To meet the requirements of these users, Magritek have produced a comprehensive list of features designed to deliver cost efficient benefits to all. Spinsolve Phosphorus offers users 1D ¹H, ¹⁹F and ³¹P experiments that use standard 5 mm NMR tubes. ³¹P can be acquired with or without proton decoupling. Proton 2D COSY and homonuclear j-resolved spectroscopy are offered along with T₁ and T₂ relaxation experiments.

Due to its large chemical shift range, the absence of impurities in the background spectrum, and the single NMR peak (after proton decoupling), ³¹P is used routinely for both purity assessment and reaction monitoring. Databases of ³¹P chemical shifts are used routinely and isomers are easily identified.

The powerful, yet easy to use software aids to the simplicity of Spinsolve Phosphorus. Uncomplicated one-button operation with a minimum amount of user controlled parameters coupled to an intuitive graphical interface means the system can easily be operated by anyone from students to experienced research chemists. For reaction monitoring applications, the system may be automated and integrates closely with the industry leading MNova data processing software from Mestrelab. The traditional NMR complexities are hidden and automated which make using a Spinsolve a short and pain-free learning experience while delivering research-grade results.

This story is reprinted from material from Magritek, with editorial changes made by Materials Today. The views expressed in this article do not necessarily represent those of Elsevier.