Natural biomaterials have evolved from multifactorial and combinatorial processes, where hierarchical organization often enables complex function beyond the sum of individual parts. To match this complexity, high-throughput/high-content approaches are necessary to expand the parameter space, towards defining structure-activity relationships between materials and biological systems.
In this webinar the current state of combinatorial and high-throughput methods for biomaterials design, discover and analysis will be described. There will be a focus on four core areas that are making a sizable impact in the biomaterials field: biomolecule microarrays, polymeric biomaterials for discover and screening, hydrogel platforms for screening multivariate cues, and biomaterials driven assays for high-content analysis.
The combination of novel screening approaches, advanced imaging, and new analysis methods are positioned to accelerate the pace of discovery for next generation materials for biotechnology and medicine.
- Learn about how high-throughput methods could accelerate biomaterials discovery.
- See how computational tools are enahncing high-content analysis.
- Find out about how high-throughput strategies are changing the way we study cell and tissue level processes.
Speakers:
Kristopher A. Kilian, Assistant Professor of Materials Science and Engineering/University of Illinois at Urbana-Champaign
Joe D'angelo, (Moderator), Materials Science Publisher, Elsevier.
Thank you for registering, and enjoy the on demand version of the webinar, below!
Bibliography:
Abdeen et al., Exp. Biol. Med. (2016) 241, 9, 930-938
Flaim et al., Nature Methods (2005) 2, 119-125
Synergistic influence of collagen I and BMP 2 drives osteogenic differentiation of mesenchymal stem cells: A cell microarray analysis
S. Rasi Ghaemi et al., Acta Biomaterialia (2016) 34, 41–52
DeForest et al., Nat. Mater. (2009) 8, 659-664
Koepsel et al., Integr. Biol. (2009) 4, 914-924
Kilian et al., Angew. Chem. Int. Ed. (2012) 51 (20), 4891-4895
Klim et al., Nat. Meth. (2010) 7 (12), 989-994
Zhang et al., J. Mater. Chem. B. (2014) 2 (27), 4280-4288
Anderson et al., Nat. Biotech. (2004) 22, 863-866
Mei et al., Nat. Mater. (2010) 9 768-778
Hydrogel arrays formed via differential wettability patterning enable combinatorial screening of stem cell behavior
Le et al., Acta Biomater. (2016) 34, 93-103
Directing stem cell fate on hydrogel substrates by controlling cell geometry, matrix mechanics and adhesion ligand composition
Lee, et al., Biomaterials (2013) 34, 8140-8148
Ranga et al., Nat. Commun. (2014) 5, 4324
A microfabricated platform with hydrogel arrays for 3D mechanical stimulation of cells
Liu et al., Acta Biomater., 2016, 34, 113-124
Unadkat et al., Proc. Nat. Acad. Sci. (2011) 108, 16565-16570
Cosson et al., Lab Chip (2013) 13, 2099-2105
Microfluidic fabrication of bioactive microgels for rapid formation and enhanced differentiation of stem cell spheroids
Siltanen et al., Acta Biomater., 2016, 34, 125-132
Gurard-Levin et al., ACS Chem. Biol. (2010), 5 (9), 863–873
Treiser et al., Proc. Nat. Acad. Sci. (2010) 107 (2), 610-615
Kwak et al., Sci. Rep. (2015) 5, 8758
Bennett et al., Curr Pharmacol Rep (2016) 2:142–151