Mimicking the Human Body in the Electron Microscope

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In a research fields investigating the chemistry and interaction of delicate, organic samples, analytical tools like X-ray crystallography, Cryo-EM, and NMR are often employed to study a “snapshot” of these materials and processes.

Unfortunately, many of the characterization tools typically available to life science and biology researchers are incapable of delivering in situ data about dynamic interactions and nanoscale structural changes in real time. With the dawn of liquid cell TEM, it is now possible to image biological samples in their native, hydrated environment at resolutions sufficient to glean information about their structural and chemical evolution in real time. This technique has already been utilized to study the RNA transcription of rotovirus particles inside the TEM, where the liquid environment inside the microscope was able to mimic temperature and chemical conditions inside the human body. In other studies, real time observation of therapeutic nanoparticle migration across the cell wall provided insights into current and future drug delivery opportunities.

In this webinar, researchers Deb Kelly and Madeline Dukes will present these and other findings on how liquid cell TEM offers unprecedented opportunities for uncovering new insights in the fields of life science and material science. They will overview the basics of liquid cell TEM, present applications and results from their research, and provide insight on the past, present, and future of life science research tools.

·      Find out why you should be using liquid cell EM to accelerate your research

·      Learn why liquid cell EM is becoming a standard tool for life sceince and biology research.

·      Discover the numerous applications benefiting from liquid cell EM, including yours.

·      See how new Protochips systems are improving lab productivity


Deborah Kelly, Assistant Professor, Virginia Tech

Madeline Dukes, Applications Scientist, Protochips

Joe d'Angelo, (Moderator), Materials Science Publisher, Elsevier.